may be a focus issue
 

If I click on anyone in game NPC or player I can not click off them unless I click myself or another or move out of range. Is this a Blizzard thing or what?

It's a change Blizzard made... press "Escape" to open the WoW menu, select "Interface" and then (I think) "Controls" -- make sure the "Sticky Targeting" option is turned off.

You the man Scott, that fixed the issue!:D Blizzard needs to add or fix things that we need not crap like that.:rolleyes: