You got the newest one today?
Did you download it or are you on the e-mail update service?
What you're describing sounds to me like one of the integrated addons is throwing an error. Are you getting any error messages?
I would suggest that you try turning off everything except nUI itself and see if it loads. If not, let me know. Otherwise, start enabling your other addons one or two at a time until it breaks again, then we'll know which addon it causing the problem and can sort it out from there.
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