Midget is not completely correct.
You can make a config addon that will setup every other addon when it is loaded 1st time.
Not that hard, but you'll have to find out how each and every addon in compilation handles it's configuration, which is quite time consuming.
As a small example, I got an addon that hides some blizzard UI elements every time game starts:
-- ClassBar behind chatframe
ShapeshiftBarFrame:SetFrameStrata("Background")
MiniMapWorldMapButton:Hide();
GameTimeFrame:Hide()
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You'd have to do the same with all other addons in compilation, moving them around and setting up it's variables.
As an alternative you can hack 3rd party addons to your preffered default settings, but some people here will QQ if you don't ask their permission first and addon does not have a license that lets you modify/redistribute it.