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I'm using F-Secure Client Security 9.x.
What I've found to make a substantial difference is to exclude World of Warcraft's installation folder from the real-time scanning engine.
It is still included in my weekly scans and nothing gets copied in it (eg. addons) without me scanning it manually and scrutinizing it.
It does make quite a difference performance-wise as it prevents the AV engine from scanning the WoW's files whenever a cache gets updated etc.
This is what I found to be causing 'stutters' when textures or data was downloaded to be cached locally, same for disc reads.
The point of this is:
Before looking for a new AV check if your current one allows you to exclude WoW's directory and processes from real-time scanning.
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