Originally Posted by SDPhantom
Having a 3D program render in native fullscreen (not windowed+noborder) usually improves performance for said program. However, switching tasks from a program in native fullscreen sometimes has unwanted side effects.
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I've actually found that I get better framerates (in WoW, at least) in windowed mode than in fullscreen mode, over a variety of hardware setups.
But, I did run WoW in fullscreen mode for several years before I set up dual monitors, and never had any issue alt-tabbing in and out of it. I've only ever had issues with alt-tabbing when the fullscreen program is running at a different resolution or color depth than the desktop, but I'm not really sure why you'd run anything at any resolution other than your monitor's native resolution -- unless you're using an ancient CRT monitor for some reason -- and I don't think I've had any program run in less than 32-bit color since the '90s.