[SDPhantom]

Long story short, the variables don't actually store the table itself. They store a pointer that tells Lua where the table data is. This means when the Ace profile changes, dbsetting remains pointing to the old table. You need to call MyAddon:SetupDrag() again to update, but there is already an inherent problem in doing so. You're wasting resources dynamically creating new functions every time you call it. To prevent this, you should create static versions of them as upvalues so they don't get recreated constantly. To handle saving their positions, each frame called in the code below will store a reference to its own profile table. Again, you still need to call MyAddon:SetupDrag() each time the profile changes to update these references.

local function Frame_OnMouseDown(self)
    if not self.isMoving then   
        self:StartMoving()
        self.isMoving = true
    end
end
 
local function Frame_OnMouseUp(self)
    if self.isMoving then
        self:StopMovingOrSizing()
        self.isMoving = false
 
        self.settings[1], self.settings[2], self.settings[3], self.settings[4], self.settings[5] = self:GetPoint(1)
    end
end
 
function MyAddon:SetupDrag(frame, settings)
    frame.settings=settings
    frame:SetScript("OnMouseDown", Frame_OnMouseDown)
    frame:SetScript("OnMouseUp", Frame_OnMouseUp)
end

PS: frame:GetPoint() needs an index saying which point you want. I'm surprised this hasn't thrown an error.