I haven't tried other layouts, but I've tried a few things with my own layouts to try and narrow this down. It seems especially bad with the nameplate implementation, even with my layout function returning on line 1 and the nameplate callback function returning on line 1.
I'm also able to see when it's oUF elements vs layout-specific elements because oUF is technically implemented as a separate addon from my 3 addons that use it. So CPU profiling shows it as it's own cpu instance.
I think part of the problem may be that the DisableBlizzard functions are not covering what they used to, I'm investigating more when I get home today.
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