I just installed Mazzle UI.
When I logged on, I followed all the steps to Mazzify. But after mazzifing the 'Fatality' error message comes up. Then all of the icons are messed up, and it doesn't look like it should. Sorry about the vague description there, but this is a screenshot someone posted on the download page that is exactly the same as mine.
www.blugh.ca/images/Maz.jpg
Basically it seems that all the addons used in the compilations have defaulted. Messy.
The only reason I can think of this happening is that I extracted the file to the main World of Warcraft file, since the addon comes with its own Interface > Addon file structure.