I have buffs displayed top-right by one addon, while debuffs I have on my player frame, handled by oUF.
Then anything that is critical to my rotation is pretty much in the middle of my screen, handled by a third addon (typically WeakAuras). This does mean I have (at times) the same buffs displayed in two places.
The main reason why the buffs are handled by a separate addon than just a pseudo-unitframe from oUF is because oUF doesn't handle cancelling buffs.
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