[Xrystal]

This is how nUI handles clicking a button during combat ( it switches display panels linked to the button ), I only maintain the addon so not all elements of the addon are fully understandable to me but I have dabbled with secure frames to fix action button issues so some of this does make some element of sense to me now. Hopefully, reading through it will give you something to help you with your own button.

local frame      = CreateFrame( "Frame", "nUI_InfoPanelSelector", background, "SecureFrameTemplate" );
frame.button     = CreateFrame( "Button", "$parent_Button", frame, "SecureHandlerClickTemplate" );
 
frame.button:SetAttribute( 
    "_onclick",
    [[
        if not IsAltKeyDown() or not IsControlKeyDown() or IsShiftKeyDown() then
                
            if button == "LeftButton" then  
                if CurrentPanel == #PanelList then
                    CurrentPanel = 1;
                else
                    CurrentPanel = CurrentPanel+1;
                end
            elseif button == "RightButton" then
                if CurrentPanel == 1 then
                    CurrentPanel = #PanelList;
                else
                    CurrentPanel = CurrentPanel-1;
                end
            end
        
            for i=1,#PanelList do
                local frame = self:GetFrameRef( PanelList[i] );
                
                if i == CurrentPanel then
                    frame:Show();
                else
                    frame:Hide();
                end
            end
        end
    ]]
);
frame.button:SetAllPoints( frame );
frame:SetAttribute( "addchild", frame.button );

Elsewhere in the code the panel list is also setup in secure mode

for item in pairs( rotation ) do        
            local name = rotation[item].name;           
            frame.button:SetAttribute( "nUI_InfoPanel"..item, name );
            frame.button:SetFrameRef( name, rotation[item].frame );
        end
 
        frame.button:Execute(
            [[
                local i = 1;
                
                PanelList = newtable();
                
                while true do
                    
                    local panel_name = self:GetAttribute( "nUI_InfoPanel"..i );
                    
                    if not panel_name then 
                        break;
                    end
                    
                    PanelList[i] = panel_name;
                    i = i+1;
                    
                end
                
                CurrentPanel = self:GetAttribute( "state" ) or 1;
            ]]
        );