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It's not possible to get a "Lite Plus" so to speak... sorry.
However, the way nUI's panels work, when you switch to a given panel, it disables all unit frames in the hidden panels. So... if you switch to the 10 man raid panel, it's as though the 40 man panel didn't exist. In other words, there would be no benefit to having a version that didn't include the bigger panels.
As for which mods do and don't impact nUI... there are no mods I know of that actually directly impact nUI itself. The combination of any two mods may have some impact on the system, but that is a variable far too complex to measure and in many cases depends more on your own system and network connection than anything else.
As far as the differences between the development and release, the biggest difference right now is that I have done a lot of optimization work in the development version that it not present in the release. If you're not running the development version, that may well be part of your frame rate problem. Even though the release version of nUI lite does not contain raid panels, it is still far more expensive in terms of its memory usage and CPU usage and the current development version. The same is true of the release version of nUI+ -- it is *far* more expensive than the development version.
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