[Fizzlemizz]

I don't have many Glyphs except a couple on a Druid (Cheetah etc.) so I'm not sure how to get one to display as active or in confict.

You do your RefreshLayout OnShow and and on receiving a GET_ITEM_INFO_RECEIVED event.

Frames by default are shown (your xml frame does not have the hidden attribute) so you won't get an initial refresh unless you receive an event or manually hide/show the frame (the OnShow script is set after the frame is created ie. already shown).