[Petrah]

When is the last time you cleaned out your saved variables? Every once in a great while it's a good idea to clean those out (there's only one that I keep, and that's Carbonite).

Also, take a look at your World of Warcraft\Logs\FrameXML.log file. Sometimes that will give away some culprits that might affect your load times. Report any errors you see to the appropriate addon author(s).