[Unkn]

Its not the same. I just use a toggle frame vs show/hide on event. I fixed it and should have a working copy below. Try it out. It is your entire layout. I just checked to make sure it worked correctly multiple times with test panels. It should work to do the following - show intended panels (ie Minimap_location and Minimap_tracking) unless you are in combat then those 2 panels will hide.

lpanels:CreateLayout("Minimap", {
        -- Bordure minimap int
        {       name = "Minimap_border",
                parent = "Minimap", anchor_to = "TOP",
                height = "100%", width = "100%" , bg_alpha = 0,
                border = "SOLID", border_color = "0 0 0",
                border_alpha = 0.5, level = 99, inset = -2.5
        },
        -- barre supérieur carte
        {       name = "Minimap_location",
                anchor_frame = "Minimap", anchor_to = "TOPLEFT",
                height = 11, width = "100%",
                bg_alpha = 0.3, level = 99,
    OnLoad=function(self)
        self:RegisterEvent'PLAYER_REGEN_ENABLED'
        self:RegisterEvent'PLAYER_REGEN_DISABLED'
        self:Show()
    end,
    OnEvent=function(self) ToggleFrame(self) end
        },     
        {       name = "Minimap_location_border",
                parent = "Minimap_location", anchor_to = "BOTTOM",
                width = "100%", height = 1, y_off = -1,
                bg_alpha = 0.5,
        },
       
        -- Barre inférieur carte
        {       name = "Minimap_tracking",
                anchor_frame = "Minimap",
                height = 18, width = "100%",
                bg_alpha = 0.3, level = 99,
    OnLoad=function(self)
        self:RegisterEvent'PLAYER_REGEN_ENABLED'
        self:RegisterEvent'PLAYER_REGEN_DISABLED'
        self:Show()
    end,
    OnEvent=function(self) ToggleFrame(self) end
               
        },
        {       name = "Minimap_tracking_border",
                parent = "Minimap_tracking", anchor_to = "TOP",
                width = "100%", height = 1, y_off = 1,
                bg_alpha = 0.5,
        },
 
        -- barre inférieur extérieur carte
        {       name = "Minimap_stat",
                parent = "Minimap_tracking", anchor_to = "BOTTOM",
                border = "SOLID", border_color = "0 0 0",
                border_alpha = 0.5, level = 0, inset = 1,
                height = 15, width = 140, y_off = -17.5,
                bg_alpha = 0.3, level = 99,
               
        }
})
 
lpanels:CreateLayout("Afker", {
    {    name = "AFK", anchor_to = "TOP", y_off = -350,
        bg_alpha = 0.5, width = 200, height = 50,
        border = "SOLID", border_color = "1 0.3 0.3",
        text = {
        -- "YOU ARE AFK!"
            {    string = "Tu es AFK !", anchor_to = "TOP", y_off = -10,
                shadow=1, font = "Fonts\\FRIZQT__.TTF", size=14,
            },
            -- "0:00" TIMER
            {    string=function()
                    if afk_timer then
                        local secs = mod(time() - afk_timer, 60)
                        local mins = floor((time() - afk_timer) / 60)
                        return format("%s:%02.f", mins, secs)
                    end
                end, update=0.1,
                shadow=1, font = "Fonts\\FRIZQT__.TTF", size=16,
                anchor_to = "CENTER", y_off = -7, color = "1 0.3 0.3"
            }
        },
        OnLoad = function(self)
            self:RegisterEvent("PLAYER_FLAGS_CHANGED")
            self:Hide()
        end,
        OnEvent = function(self)
            if UnitIsAFK("player") and not afk_timer then
                self.text2:SetText("0:00")
                afk_timer = time()
                self:Show()
            elseif not UnitIsAFK("player") then
                self:Hide()
                afk_timer = nil
            end
        end,
        OnClick = function(self, b)
            self:Hide()
            if b == "LeftButton" then SendChatMessage("", "AFK") end
        end,
        OnEnter = function(self) self.bg:SetTexture(.1,.1,.1,.5) end,
        OnLeave = function(self) self.bg:SetTexture(0,0,0,.5) end
    }
})
 
lpanels:ApplyLayout(nil, "Minimap", "Afker")