Probably a tiny thing to comment on, but I love how the border of your bottom panel stops at the chat frame border. It gives an illusion of invisibility, me like.
I'd change your minimap to be a bit smaller though, so it matches chat frame height. It looks a little unbalanced now. Also, ever considered semi-transparent castbar background?
Castbar at the top looks a little out of place, too, for a bottom-centered UI. I'd have a hard time noticing it.
And change your quest tracker font.
You can use mine if you like (I based mine on Seerah's code, anyways).