Are you playing classic or retail? This will change which API you need for the quest log and inventory.
I don't think an addon will be able to tell you where on your screen is an in-game objects, but maybe you could hook some tooltip functions to be informed when the mouse cursor is over an object that results in a tooltip?
In outdoor zones, on retail only, the new waypoint system can be used to help you get your bearings for whatever quest you are on.
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