I'd like to add one thing. If you're feeling really clever, you can put multiple spells in each spot in priority order. The Mazzifier will choose the first spell it finds. It will only put a spell in one button in a particular bar.
For example, let's say you had a 2-button bar for some mage talent skills
C - Presence of Mind, Combustion
X - Arcane Power, Combustion
So, if a mage's talents gave him POM and AP, C would be POM and X would be AP. If another mage had POM, no AP and combustion, C would be POM and X would be combustion. If yet another mage had only combustion, C would be combustion and X would be empty.
I also use these priority lists to make layouts that work well for classes of different levels. For example:
1 - Greater Heal, Heal, Lesser Heal
2 - Heal, Lesser Heal
3 - Lesser Heal
This would result in a bar (albeit a small one) that always had the largest spell bound to 1, regardless of what level you are.
And remember, like Joypunk said, I'm only looking for layouts that augment the current layouts for the BC spells. I don't want wildly different bindings and philosophies. If you do feel strongly about a change, just make a good argument for it.
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