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The WoW API doesn't allow addons to be unloaded in game without a UI reload. You can make a "disable" button which turns off processing and tries to free as much memory as possible -- which may be what you're asking for -- but I really don't see why you would prefer that over just preventing the addon from loading in the first place, if it is crashing the whole game, since in that case why would you keep using it?
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