(Posted this in "action bars don't work")
What I noticed is that in the Grid and Bartender preferences pane, in the profiles tab, there is a (new?) checkbox preventing the setting of non-character profiles labeled "Enable spec profiles." Uncheck that and you can select "RealUI" from your existing profiles list.
I'd do that for all your addons. While RealUI does have an automated set-up, you can do a lot of it manually as well.
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