Yes, it should be possible, although I haven't tried it yet
A good start is looking in Blizzard's QuestFrame-code - I don't know how familiar you are with WoW-AddOns (the code looks rather complicated on first view), but you get a lot of the functions to hook or frame names out of it.
FrameXML/QuestFrame.lua
FrameXML/QuestFrame.xml