1. Your buffs are in no discernable order.
2. I don't really like how your health and mana bars are separate blocks. It makes the whole unit frame look like a cluttered blob of unrelated things that just happened to be dumped in the same spot on the screen.
3. The barely-visible reputation bar at the top of the screen is distracting. I assume it becomes opaque on mouseover... if so, it might better to make it completely invisible until moused over, or turn one of the black bars at the top/bottom of the screen into a rep bar.
4. Finally, I feel like the boss timer bars are not in a great place. Right now you've got boss unit frames and raid unit frames in opposite corners of the screen, so that's already a lot of looking around you have to do to see what's going on. It seems like the boss timers would be better placed directly above the boss frames, or directly below the raid frames.