If you're thinking about the damage/healing numbers that appear above the targets when you damage or heal them, they cannot be changed as they are part of the game world, not the UI.
The only alternative you've got is to disable it and use an addon to display it in a static location (as most alternatives do).
You could possibly make an addon that anchors them to nameplates, but because of how nameplates work and the fact that they don't have any identifiers usable for matching with the combat log (unless you've put your cursor over them once then cached them), it's not a feasible solution (imo).
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