[Fizzlemizz]

Using the Pastebin code and assuming all your button names are consistant starting with "NewbDevBoxButtonFrame" and prefixed with the name in ButtonTable ie.

local xxx = CreateFrame("Button", "NewbDevBoxButtonFrameLogoutButton", NewbDevBoxButtonFrame, "SecureActionButtonTemplate, GameMenuButtonTemplate")

You could use:

local function buttonFrameButtonLayout()
    for k, v in pairs(ButtonTable) do
        thisButton = _G["NewbDevBoxButtonFrame"..k] -- use the name to get the button from the global table.
        thisButton:ClearAllPoints()
            -- ...
        end
    end
end

Edit: typos.