Copied and Pasted from "The Document that can't be mentioned"
1- Many of the standard Blizzard bindings have been changed, especially the ones on the left hand side of the keyboard. Those keys are quite valuable in combat because they can be quickly reached while your other fingers stay on WASD. Rather than have those keys pull up non-combat stuff like the character window, they have been reassigned to combat functions.
Most of the standard button assignments have been changed to their ctrl-key equivalents. For example, you can pull up your character window with ctrl-c in most layouts.
2- The context menu is a set of 16 buttons arranged in a square that is hidden most of the time you are playing. You can unhide it at any point by click Shift-Mousebutton4, Shift-MiddleMouseButton or by clicking the context menu HotSpot (middle right corner the MazzleUI bottom panel). It will then appear under your mouse for quick access.
The context menu is an excellent place to put non-combat skills and spells. It keeps things out of your way and makes your UI a little bit more efficient. By default, the Mazzifier should put all of your trade skills and hearthstone in the context menu. For some classes, it will also put things like conjuring or pet summon spells. Remember that there are two pages to the context menu. You can switch pages by using your mousewheel while over the context menu.
Note: There are several options you can use to configure your context menu. These options include whether the context menu auto-hides after you use something in it, whether the context menu moves to your mouse location, and whether the UI will automatically hide the context menu when you first log in. These can all be accessed under the 'MazzleUI General Settings' category of MazzleOptions.